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Thrombus formation and the subsequent activation of the coagulation cascade with final generation of fibrin is facilitated by the mCRP-mediated enhancement of tissue factor on the endothelial cell surface, platelet aggregation and thrombus growth (207, 208) (Figure 7)

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TABLE 2

Coplan JD, Mathew SJ, Mao X, Smith ELP, Hof PR, Coplan PM, et al

This Nrf2 activation may work in concert with the SAHH-dependent maintenance of the transsulfuration pathway, creating a multi-layered defense system wherein DJ-1 coordinately enhances both the synthesis (via transsulfuration) and the utilization (via Nrf2-target genes like GCLM) of glutathione